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The little-explored therapeutic potential of nanoformulations of 1,25-dihydroxyvitamin D3 and its active analogs in prevalent inflammatory and oxidative disorders

    Virna Margarita Martín Giménez

    Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, San Juan, Argentina

    , ,
    León Ferder

    Department of Pediatrics, Nephrology Division, Miller School of Medicine, University of Miami, FL, USA

    The University of Maimonides, Buenos Aires, Argentina

    ,
    Michael F Holick

    *Author for correspondence:

    E-mail Address: mfholick@bu.edu

    Section on Endocrinology, Diabetes, Nutrition & Weight Management, Department of Medicine, Boston University, School of Medicine, Boston, MA 02118, USA

    &
    Walter Manucha

    **Author for correspondence:

    E-mail Address: wmanucha@gmail.com

    Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Mendoza, Argentina

    Published Online:https://doi.org/10.2217/nnm-2021-0284
    Free first page

    References

    • 1. Charoenngam N, Holick MF. Immunologic effects of vitamin D on human health and disease. Nutrients 12(7), 2097 (2020).
    • 2. Mariani J, Giménez VMM, Bergam I et al. Association between vitamin D deficiency and COVID-19 incidence, complications, and mortality in 46 countries: an ecological study. Health Secur. 19(3), 302–308 (2021).
    • 3. Martín Giménez VM, Inserra F, Ferder L et al. Vitamin D deficiency in African Americans is associated with a high risk of severe disease and mortality by SARS-CoV-2. J. Hum. Hypertens. 35(4), 378–380 (2021).
    • 4. Cannell JJ, Grant WB, Holick MF. Vitamin D and inflammation. Dermato-endocrinology 6(1), e983401 (2015).
    • 5. Charoenngam N, Shirvani A, Holick MF. Vitamin D and its potential benefit for the COVID-19 pandemic. Endocr. Pract. 27(5), 484–493 (2021).
    • 6. Giménez VMM, Sanz RL, Marón FJM et al. Vitamin D-RAAS connection: an integrative standpoint into cardiovascular and neuroinflammatory disorders. Curr. Protein Pept. Sci. 21(10), 948–954 (2020).
    • 7. Martín Giménez VM, Inserra F, Tajer CD et al. Lungs as target of COVID-19 infection: protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment. Life Sci. 254, 117808 (2020).
    • 8. De Las Heras N, Martín Giménez VM, Ferder L et al. Implications of oxidative stress and potential role of mitochondrial dysfunction in COVID-19: therapeutic effects of vitamin D. Antioxidants (Basel) 9(9), 897 (2020).
    • 9. Martín Giménez VM, Bergam I, Reiter RJ et al. Metal ion homeostasis with emphasis on zinc and copper: potential crucial link to explain the non-classical antioxidative properties of vitamin D and melatonin. Life Sci. 281, 119770 (2021).
    • 10. Martín Giménez VM, Ferder L, Inserra F et al. Differences in RAAS/vitamin D linked to genetics and socioeconomic factors could explain the higher mortality rate in African Americans with COVID-19. Ther. Adv. Cardiovasc. Dis. 14, 1753944720977715 (2020).
    • 11. Sadarangani SP, Whitaker JA, Poland GA. “Let there be light”: the role of vitamin D in the immune response to vaccines. Expert Rev. Vaccines 14(11), 1427–1440 (2015).
    • 12. Feldman D, Krishnan AV, Swami S et al. The role of vitamin D in reducing cancer risk and progression. Nat. Rev. Cancer 14(5), 342–357 (2014).
    • 13. Maurya VK, Bashir K, Aggarwal M. Vitamin D microencapsulation and fortification: trends and technologies. J. Steroid Biochem. Mol. Biol. 196, 105489 (2020).
    • 14. Lincha VR, Zhao J, Wen X et al. A polymeric micellar drug delivery system developed through a design of experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. Int. J. Pharm. 601, 120523 (2021).
    • 15. Markman G, Livney YD. Maillard-conjugate based core-shell co-assemblies for nanoencapsulation of hydrophobic nutraceuticals in clear beverages. Food Funct. 3(3), 262–270 (2012).
    • 16. Li W, Peng H, Ning F et al. Amphiphilic chitosan derivative-based core-shell micelles: synthesis, characterisation and properties for sustained release of vitamin D3. Food Chem. 152, 307–315 (2014).
    • 17. Mu Y, Li J, Kang JH et al. A lipid-based nanocarrier containing active vitamin D3 ameliorates NASH in mice via direct and intestine-mediated effects on liver inflammation. Biol. Pharm. Bull. 43(9), 1413–1420 (2020).
    • 18. Gavin PD, El-Tamimy M, Keah HH et al. Tocopheryl phosphate mixture (TPM) as a novel lipid-based transdermal drug delivery carrier: formulation and evaluation. Drug Deliv. Transl. Res. 7(1), 53–65 (2017).
    • 19. Glowka E, Stasiak J, Lulek J. Drug delivery systems for vitamin D supplementation and therapy. Pharmaceutics 11(7), 347 (2019).
    • 20. Ślusarczyk J, Piotrowski M, Szczepanowicz K et al. Nanocapsules with polyelectrolyte shell as a platform for 1,25-dihydroxyvitamin D3 neuroprotection: study in organotypic hippocampal slices. Neurotox. Res. 30(4), 581–592 (2016).
    • 21. Demer LL, Hsu JJ, Tintut Y. Steroid hormone vitamin D: implications for cardiovascular disease. Circ. Res. 122(11), 1576–1585 (2018).
    • 22. Yi S, Karabin NB, Zhu J et al. An injectable hydrogel platform for sustained delivery of anti-inflammatory nanocarriers and induction of regulatory T cells in atherosclerosis. Front. Bioeng. Biotechnol. 8, 542 (2020).